منابع مشابه
Ion Channels and Synaptic Organization Analysis of the Drosophila Genome
larvae (Jan and Jan, 1976) facilitated studies at the cellular level and stimulated the isolation of mutants that perturbed neuronal signaling. This genetic strategy made it possible to identify and ultimately to isolate genes encoding ion channel proteins that had been re-ether-sensitive leg-shaking phenotype (Kaplan and Trout, 1969), Sh was subsequently shown to cause prolonged transmitter re...
متن کاملThe role of synaptic ion channels in synaptic plasticity.
The nervous system receives a large amount of information about the environment through elaborate sensory routes. Processing and integration of these wide-ranging inputs often results in long-term behavioural alterations as a result of past experiences. These relatively permanent changes in behaviour are manifestations of the capacity of the nervous system for learning and memory. At the cellul...
متن کاملIon channels in synaptic vesicles from Torpedo electric organ.
A simple method has been developed for fusing synaptic vesicles into spherical structures 20-50 micron in diameter. The method has been applied to purified cholinergic synaptic vesicles from Torpedo electric organ, and the membrane properties of these fused structures have been studied by the "cell"-attached version of the patch clamp technique. A large conductance potassium-preferring channel,...
متن کاملEffect of general anaesthetics on synaptic ion channels.
General anaesthetics are a large group of physiologically active substances which, although structurally diverse, are generally regarded as possessing one common physical-chemical property—a high solubility in hydrophobic solvents. Clinically, general anaesthetics have the well known and very useful properties of being able to abolish sensation and to produce unconsciousness, and are thus used ...
متن کاملO 13: Ion Channels in Autoimmune Neurodegeneration
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by widespread inflammation, focal demyelination and a variable degree of axonal and neuronal loss. Ionic conductances regulate T cell activation as well as neuronal function and thus have been found to play a crucial role in MS pathogenesis. Since present therapeutical approaches are only parti...
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ژورنال
عنوان ژورنال: Neuron
سال: 2000
ISSN: 0896-6273
DOI: 10.1016/s0896-6273(00)81135-6